Magnesium treatment in alcoholics: A randomized clinical trial PMC

Thus, the aim of the present review article was to examine the current knowledge on vitamin deficiency and its role in chronic liver disease. Numerous studies have described that vitamin supplementation could reduce hepatotoxicity. However, further studies with reference to the changes in vitamin status and the nutritional management of chronic liver disease are in demand. As shown in Table 2, severe ALD micronutrient deficiencies are expected in patients, and thus, supplementation is needed. Vitamins, which are molecules found in small amounts in various foods, are essential for normal metabolism, and deficient vitamin levels in the body can lead to serious diseases.

• Addiction psychiatrists provide both medications and talk therapy while others focus on prescribing meds.
• Ethical approval for the trial was granted by the Ethics Committee of the Helsinki and Uudenmaa Hospital District (Dno 80/E7/2002).
• Too little could eventually cause serious learning and memory problems, a condition called Wernicke-Korsakoff’s syndrome.
• However, recommendations vary depending on the pathophysiology of ALD and the presence or absence of glucose intolerance [54].

N-Acetyl-Cysteine and Vitamin C

A supplement that covers all of your nutritional bases helps you recover. A lack of vitamin B9 can trigger anemia and make you weak, tired, and moody. Folic acid is in foods like enriched bread, flour, cornmeal, pasta, rice, and breakfast cereals. best supplement for alcoholics Veggies, fruits, fruit juices, nuts, beans, and peas naturally have folate. Research published in 2022 found that individuals who were alcohol dependent had significantly lower levels of both zinc and magnesium compared to the control group.

Best Supplements for Alcohol Recovery

For the average person who is eating a well-balanced, healthy diet, supplements of vitamins B and C are often unnecessary. However, alcohol abusers will find that a holistic approach to recovery that integrates a nourishing diet and this type of vitamin supplementation helps them through the process. Concentrating on regaining good health can maximize the chances of success in recovery from addiction and set recovering alcoholics on the right path to a new life. Previous research has linked alterations in methionine metabolism to ethanol-induced alcoholic liver damage [113,114,115]. Several research articles have linked alcohol-mediated oxidative stress and ethanol-inducible CYP2E1 with oxidative stress and their toxicity, both in in vitro and in vivo models. In effect, new pathophysiological focuses that could be used against ALD have been described using in vitro studies [29,30].

Can vitamins protect the brain from alcohol’s adverse effects?

• It’s important to note that most standard glutathione supplements get broken down by the your digestive tract and do not enter your bloodstream.
• Individuals with alcohol use disorder may experience deficiencies in vitamins such as vitamin B.
• However, it lacked the classic warmth of an old fashioned and, at times, it even had a slightly medicinal taste rather than an herbal one.
• Chronic alcohol abuse causes significant magnesium deficiencies [142].
• It is also important to note that SAM inhibits MTHFR while promoting CBS expression.

The patients received orally for 8 weeks either a daily dose of 500 mg (20 mmol) of Mg tablets divided in two tablets (250 mg each) or matching placebo tablets. The tablets contained a mixture of magnesium carbonate, magnesium acetate and magnesium hydroxide. This mixture is the best compromise between a good uptake without any laxative effects. The magnesium acetate is valuable if someone has low stomach acid, because it can be absorbed even in this case. The tablets were dispensed in blister packs with 30 tablets in each.

Magnesium supplements can improve cognitive deficits caused by chronic alcohol abuse by improving cerebral blood flow10. While people naturally produce some vitamins or receive them from healthy food, taking dietary supplements is a great way to deal with nutrient deficiency. Vitamins B6 and B12 play important roles in producing blood cells and supporting the health of the nervous system. Other good sources of vitamin B6 include bananas, avocados, and peanuts.

• Animal studies have shown that Mg deficiency aggravates the hepatic damage caused by alcohol [4].
• Research suggests certain B vitamins can help treat alcoholic liver disease by alleviating alcohol-induced oxidative stress8.
• However, treatment recommendations for elevated manganese level are currently unknown.
• The effect of Mg was studied in a randomized, parallel group, double-blind trial.
• After controlling for the possible confounders, the after-treatment S-AST levels were found to be lower in the Mg-treated group than in the respective placebo group among the study completers.

Are There Certain Vitamins that Help Decrease Liver Enzymes?

• Hyperhomocysteinemia induced by ethanol and linked to oxidative endoplasmic reticulum stress triggers apoptosis and increases lipid production [112].
• Limited information is available about whether selenium is helpful in those who struggle with alcohol or during alcohol withdrawal.
• Anyone dealing with a more serious alcohol use disorder, on the other hand, should seek help from a professional.
• I created and take the Optimal Antiox supplement and the Optimal Energy supplement before and after drinking, and they contain many of the antioxidants mentioned above.

Activated charcoal is a potent natural treatment that can trap toxins and chemicals, allowing them to be flushed out of your body. Some other protective antioxidants include CoQ10, quercetin, grape seed extract, Vitamin E, selenium and resveratrol. As I mentioned above, Vitamin B1 (thiamine) is the most important B vitamin to take when consuming alcohol.

Get the Help You Need to Overcome AUD

When you drink, the process of metabolizing alcohol utilizes nutrients in your body. The liver breaks down most of the alcohol you drink so that it can be removed from the body. When the level of essential nutrients decreases in your liver the bloodstream is called upon to replenish it. As a result, body cells are deprived of critical nutrients and normal body functions can suffer. Nutritional strategies may be helpful for the treatment of alcoholics, including those with ALD.

Milk thistle is known to contain a special antioxidant and anti-inflammatory compound called silymarin which may be important for its protective effect on the liver. According to the University of Maryland Medical Center, the scientific evidence for the effectiveness of milk thistle on alcoholic liver disease shows both positive and negative results 2. However they point out the majority of studies seem to support an improvement in liver function and an increase in survival for patients with advanced liver disease. Zinc supplements may also support healthy liver function for chronic alcohol drinkers.

Apothekary’s Stop Your Wine-ing Supplement

When compared to those who do not consume alcohol, urine ascorbic acid excretion increased by 47% after acute alcohol consumption of up to 0.58 g ethanol/kg body weight [61]. Furthermore, short-term intravenous vitamin C therapy (500 mg/day for five days) significantly improved serum vitamin C levels in chronic alcoholics with hypovitaminosis C [64]. Despite these findings, a previous study indicated that chronic drinkers’ blood levels can take up to three months to restore to normal after taking oral vitamin C supplements [65,66]. Due to decreased hepatic storage, vitamin B9 and vitamin B12 deficiencies can develop quickly in chronic liver illness. However, alcohol consumption affects the metabolism of homocysteine (tHcy) because the enzyme cofactor for the conversion of tHcy to methionine is vitamin B12.